Prostaglandin E<ce:inf loc=post>2</ce:inf> in the midbrain periaqueductal gray produces hyperalgesia and activates pain-modulating circuitry in the rostral ventromedial medulla

@article{Heinricher2004ProstaglandinEL,
  title={Prostaglandin E<ce:inf loc=post>2</ce:inf> in the midbrain periaqueductal gray produces hyperalgesia and activates pain-modulating circuitry in the rostral ventromedial medulla},
  author={Mary Magdalen Heinricher and Melissa E Martenson and Miranda J Neubert},
  journal={Pain},
  year={2004},
  volume={110},
  pages={419-426}
}
Recent years have seen significant advances in our understanding of the peripheral and spinal mechanisms through which prostaglandins contribute to nociceptive sensitization. By contrast, the possibility of a supraspinal contribution of these compounds to facilitated pain states has received relatively little attention. One possible mechanism through which prostaglandins could act supraspinally to facilitate nociception would be by recruitment of descending facilitation from brainstem pain… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

Periaqueductal Grey EP3 Receptors Facilitate Spinal Nociception in Arthritic Secondary Hypersensitivity.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2016
View 10 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…