Prostaglandin E(2) inhibits calcium current in two sub-populations of acutely isolated mouse trigeminal sensory neurons.

@article{Borgland2002ProstaglandinEI,
  title={Prostaglandin E(2) inhibits calcium current in two sub-populations of acutely isolated mouse trigeminal sensory neurons.},
  author={Stephanie L Borgland and Mark Connor and Renae M Ryan and Helen J. Ball and Macdonald J Christie},
  journal={The Journal of physiology},
  year={2002},
  volume={539 Pt 2},
  pages={433-44}
}
Prostaglandins are important mediators of pain and inflammation. We have examined the effects of prostanoids on voltage-activated calcium currents (I(Ca)) in acutely isolated mouse trigeminal sensory neurons, using standard whole cell voltage clamp techniques. Trigeminal neurons were divided into two populations based on the presence (Type 2) or absence (Type 1) of low voltage-activated T-type I(Ca). The absence of T-type I(Ca) is highly correlated with sensitivity to mu-opioid agonists and the… CONTINUE READING
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