Prostaglandin E(2) induces caspase-dependent apoptosis in rat cortical cells.

  title={Prostaglandin E(2) induces caspase-dependent apoptosis in rat cortical cells.},
  author={Tsuneo Takadera and Hiroshi Yumoto and Yoshiko Tozuka and Takao Ohyashiki},
  journal={Neuroscience letters},
  volume={317 2},
Up-regulation of neuronal cyclooxygenase-2 (COX-2) and the elevation in prostaglandin E(2) (PGE(2)) have been reported to occur after cerebral ischemic insult. To evaluate whether the COX-2 reaction product PGE(2) is directly related to induction of apoptosis in neuronal cells, the effect of PGE(2) on cell viability was examined in rat cortical cells. PGE(2) induced apoptosis in a dose-dependent manner (5-25 microM) 48 h after addition to the cells, which was characterized by cell shrinkage… CONTINUE READING


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