Prostaglandin E(2) and misoprostol induce neurite retraction in Neuro-2a cells.

@article{Tamiji2010ProstaglandinEA,
  title={Prostaglandin E(2) and misoprostol induce neurite retraction in Neuro-2a cells.},
  author={Javaneh Tamiji and Dorota A Crawford},
  journal={Biochemical and biophysical research communications},
  year={2010},
  volume={398 3},
  pages={450-6}
}
Prostaglandin E(2) (PGE(2)) is a key lipid-derived compound which mediates important physiological functions in the nervous system via activation of four EP receptors (EP1-4). Recent studies have shown that altered PGE(2) signalling due to abnormal lipid peroxidation and oxidative stress may underlie some pathologies of the nervous system. The prenatal exposure to the drug misoprostol, a prostaglandin type E analogue, has also been linked to a number of neurodevelopmental defects. In the… CONTINUE READING

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