Prostaglandin D2 induces IL-8 and GM-CSF by bronchial epithelial cells in a CRTH2-independent pathway.

Abstract

BACKGROUND Prostaglandin D(2) (PGD(2)), a major prostanoid produced by activated mast cells, has long been implicated in allergic diseases. PGD(2) demonstrates its effects through two G-protein-coupled receptors, DP and CRTH2. The PGD(2)/CRTH2 system mediates chemotaxis of eosinophils, basophils, and Th2 cells, which are involved in the induction of… (More)

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Cite this paper

@article{Chiba2006ProstaglandinDI, title={Prostaglandin D2 induces IL-8 and GM-CSF by bronchial epithelial cells in a CRTH2-independent pathway.}, author={Takahito Chiba and Akira Kanda and Shigeharu Ueki and Wataru Ito and Yumiko Kamada and Hajime Oyamada and Norihiro Saito and Hiroyuki Kayaba and Junichi Chihara}, journal={International archives of allergy and immunology}, year={2006}, volume={141 3}, pages={300-7} }