Prostaglandin D2-induced eosinophilic airway inflammation is mediated by CRTH2 receptor.

  title={Prostaglandin D2-induced eosinophilic airway inflammation is mediated by CRTH2 receptor.},
  author={Yoshiki Shiraishi and Koichiro Asano and Takeshi Nakajima and Tsuyoshi Oguma and Yusuke Suzuki and Tetsuya Shiomi and Koichi Sayama and Kyoko Niimi and Misa Wakaki and Junko Kagyo and Eiji Ikeda and Hiroyuki Hirai and Kazuhiro Yamaguchi and Akitoshi Ishizaka},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={312 3},
Mast cell-derived prostaglandin D(2) (PGD(2)) is one of the essential modulators of eosinophilic airway inflammation in asthma and allergic rhinitis. Two G protein-coupled receptors for PGD(2), prostaglandin D(2) receptor (DP) and chemoattractant receptor-homologous molecule expressed on Th(2) cells (CRTH2), are both expressed on the surface of eosinophils, and CRTH2 has been demonstrated to mediate PGD(2)-induced eosinophil mobilization in vitro. However, it has not yet been determined whether… CONTINUE READING


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