Prostaglandin D₂ pathway upregulation: relation to asthma severity, control, and TH2 inflammation.

Abstract

BACKGROUND Bronchoalveolar lavage (BAL) fluid prostaglandin D₂(PGD₂) levels are increased in patients with severe, poorly controlled asthma in association with epithelial mast cells (MCs). PGD₂, which is generated by hematopoietic prostaglandin D synthase (HPGDS), acts on 3 G protein-coupled receptors, including chemoattractant receptor-homologous molecule… (More)
DOI: 10.1016/j.jaci.2013.01.035

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Cite this paper

@article{Fajt2013ProstaglandinDP, title={Prostaglandin D₂ pathway upregulation: relation to asthma severity, control, and TH2 inflammation.}, author={Merritt L Fajt and Stacy L. Gelhaus and Bruce D. Freeman and Crystal E Uvalle and John B. Trudeau and Fernando Holgu{\'i}n and Sally E Wenzel}, journal={The Journal of allergy and clinical immunology}, year={2013}, volume={131 6}, pages={1504-12} }