Prostaglandin Control of the Renal Circulation in Response to Hypoxemia in the Fetal Lamb in Utero

@article{Millard1979ProstaglandinCO,
  title={Prostaglandin Control of the Renal Circulation in Response to Hypoxemia in the Fetal Lamb in Utero},
  author={Ronald W. Millard and H Baig and Stephen F. Vatner},
  journal={Circulation Research},
  year={1979},
  volume={45},
  pages={172–179}
}
We studied the effects of 10-minute periods of hypoxemia in unanesthetized fetal lambs in utero instrumented for measurements of arterial pressure and renal and iliac blood flows. Fetal hypoxemia, induced by delivering a hypoxic gas mixture to the ewe, was characterized by a reduction in fetal Path from 20.1 ± 1.4 to 8.8 ± 1.0 mm Hg (mean ± SE). The fetus responded with bradycardia and persistent vasoconstriction in the iliac bed throughout the 10-minute period. In contrast, renal resistance… 
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42 Citations
Background Citations
4
Methods Citations
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42 Citations

Citation Type

Citation Type

Developmental Aspects of the Renal Response to Hypoxemia in the Lamb Fetus
TLDR
It appears that the response of the Fetal kidney to hypoxemia depends on the degree of fetal maturation, and the ability of the fetal kidney to reabsorb free water is more developed in near-term fetuses.
Renal responses to prolonged (48 h) hypoxemia without acidemia in the late-gestation ovine fetus.
TLDR
It is concluded that hypoxemia without acidemia results in an immediate and considerable increase in fetal renal blood flow, which remains elevated for the entire hypoxemic period.
Chronic Hypoxia Alters Vasoconstrictive Responses of Femoral Artery in the Fetal Sheep
TLDR
It is concluded that mild chronic hypoxia seems to increase the fetal femoral artery response to PE, but not in the fetal renal artery, which is consistent with a redistribution of cardiac output away from the carcass.
The role of carotid chemoreceptors in the effects of hypoxia on renal blood flow in the late gestation sheep fetus
TLDR
The initial fall in RBF during hypoxia is a carotid chemoreflex but other mechanisms, e.g. vasoconstrictor hormones, contribute to the sustained response.
Baroreceptor and prostanoid control of fetal renal cortical blood flow and plasma renin activity.
TLDR
Test the role of prostaglandins and their interaction with arterial baroreceptors and chemoreceptors in the control of renal cortical blood flow during hypotension produced by vena caval obstruction in late-gestation fetal sheep and it is concluded that both arterialbars and prostanoids influence renal blood flow.
The effect of the inhibition of prostaglandin synthesis on renal blood flow in fetal sheep.
Renal responses to prolonged (48 h) hypoxemia without acidemia in the late-gestation ovine fetus.
TLDR
It is concluded that hypoxemia without acidemia results in an immediate and considerable increase in fetal renal blood flow, which remains elevated for the entire hypoxemic period.
Effects of inhibition of prostaglandin synthesis on fetal renal function.
TLDR
The inability of indomethacin to render the urine hypertonic indicates that the inability of the fetal kidney to concentrate is probably not due to endogenous activity of the renal prostaglandin system, and the increase in sodium chloride excretion with a concomitant reduction of RBF is a pattern not previously reported following inhibition of prostag landin production.
Effects of Indomethacin upon Cerebral Hemodynamics of Newborn Pigs
TLDR
It is concluded that intravenous administration of indomethacin decreases cerebral blood flow and attenuates cerebral hyperemia induced by severe, combined hypoxia/hypercapnia in newborn pigs.
Mechanisms of beat-to-beat variability in the heart rate of the neonatal lamb. II. Effects of hypoxia.
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References

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