Prostacyclin synthase gene: genetic polymorphisms and prevention of some cardiovascular diseases.

  • Tomohiro Nakayama
  • Published 2005 in
    Current medicinal chemistry. Cardiovascular and…


Prostacyclin (PGI2) inhibits platelet aggregation and vasoconstriction. Prostacyclin synthase (PGIS), a catalyst of PGI2 synthesis from prostaglandin H2, is widely distributed and predominantly found in vascular endothelial and smooth muscle cells. The PGIS gene is localized to 20q13.11-13, and a candidate gene for cardiovascular disease. We discovered… (More)


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