Prostacyclin regulates spinal nociceptive processing through cyclic adenosine monophosphate-induced translocation of glutamate receptors.

@article{Schuh2014ProstacyclinRS,
  title={Prostacyclin regulates spinal nociceptive processing through cyclic adenosine monophosphate-induced translocation of glutamate receptors.},
  author={Claus Dieter Schuh and Christian Brenneis and Dong Dong Zhang and Carlo Angioni and Yannick Schreiber and Nerea Ferreiros-Bouzas and Sandra C. Pierre and Marina Henke and Bona Linke and Rolf N{\"u}sing and Klaus Scholich and Gerd 7 Geisslinger},
  journal={Anesthesiology},
  year={2014},
  volume={120 2},
  pages={447-58}
}
BACKGROUND Prostacyclin (PGI2) is known to be an important mediator of peripheral pain sensation (nociception) whereas little is known about its role in central sensitization. METHODS The levels of the stable PGI2-metabolite 6-keto-prostaglandin F1α (6-keto-PGF1α) and of prostaglandin E2 (PGE2) were measured in the dorsal horn with the use of mass spectrometry after peripheral inflammation. Expression of the prostanoid receptors was determined by immunohistology. Effects of prostacyclin… CONTINUE READING