Prostacyclin-mediated compensatory mechanism in the coronary circulation during acute NO synthase blockade.

@article{Lacza2003ProstacyclinmediatedCM,
  title={Prostacyclin-mediated compensatory mechanism in the coronary circulation during acute NO synthase blockade.},
  author={Zsombor Lacza and L{\'a}szl{\'o} D{\'e}zsi and Krisztina K{\'a}ldi and Eszter M Horv{\'a}th and P{\'e}ter S{\'a}ndor and Zolt{\'a}n Beny{\'o}},
  journal={Life sciences},
  year={2003},
  volume={73 9},
  pages={1141-9}
}
Nitric oxide (NO) in contrast to most prostanoids, plays a major role in the maintenance of coronary arterial tone under physiological conditions. However, in case of endothelial damage or other NO-depleting situations the importance of other vasodilating mechanisms may be increased. The aim of the present study was to investigate the crosstalk between the L-arginine - NO and the prostanoid systems in isolated rat hearts. Coronary flow and cardiac dynamics were measured in a standard… CONTINUE READING