Prostacyclin induction by high-density lipoprotein (HDL) in vascular smooth muscle cells depends on sphingosine 1-phosphate receptors: effect of simvastatin.

@article{GonzlezDez2008ProstacyclinIB,
  title={Prostacyclin induction by high-density lipoprotein (HDL) in vascular smooth muscle cells depends on sphingosine 1-phosphate receptors: effect of simvastatin.},
  author={Mar{\'i}a Gonz{\'a}lez-D{\'i}ez and Cristina Rodr{\'i}guez and Lina Badim{\'o}n and Jos{\'e} Mart{\'i}nez-Gonz{\'a}lez},
  journal={Thrombosis and haemostasis},
  year={2008},
  volume={100 1},
  pages={
          119-26
        }
}
Prostacyclin (PGI2) is an important regulator of vascular homeostasis. Our goal was to analyze the role of sphingosine 1-phosphate (S1P) and its receptors in the up-regulation of cyclooxygenase-2 (Cox-2) induced by HDL in human vascular smooth muscle cells (VSMC). S1P induces Cox-2 expression in a time-and dose-dependent manner at concentrations (0.02-1 microM) compatible with those present in physiological HDL levels. The effect was mimicked by dihydro-S1P (DhS1P), a S1P derivative that only… 
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Cyclooxygenase-2 expression, prostacyclin production and endothelial protection of high-density lipoprotein.
TLDR
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