Prostacyclin and iloprost: Equal efficiency in preserving high energy phosphates in the dog heart following coronary artery ligation

@article{Pissarek1987ProstacyclinAI,
  title={Prostacyclin and iloprost: Equal efficiency in preserving high energy phosphates in the dog heart following coronary artery ligation},
  author={Margit Pissarek and Henk J. Th. Goos and J. N{\"o}hring and Jesper Graff and G L Buller and Inge Beyerd{\"o}rfer and H. -J. Mest and K. -F. Lindenau and Prof. E. -G. Krause},
  journal={Basic Research in Cardiology},
  year={1987},
  volume={82},
  pages={566-575}
}
The influence of PGI2 and iloprost on the contents of high energy phosphates, cAMP, glycolytic metabolites and on cardiac performance was investigated in open-chest dogs subjected to 3 h of ischaemia, induced by occlusion of the left anterior descending coronary artery. The administration of drugs for 2h, starting 1h after the onset of ischaemia, resulted in a normalization and an appreciable reduction in the loss of high energy phosphates in the non — ischaemic and ischaemic left ventricular… CONTINUE READING