Prostacyclin and cerebral vessel relaxation.

  title={Prostacyclin and cerebral vessel relaxation.},
  author={Kimberly S. Paul and Eric T. Whalley and Ch. Forster and R. H. Lye and Jonathan Dutton},
  journal={Journal of neurosurgery},
  volume={57 3},
The authors have studied the ability of prostacyclin to reverse contractions of human basilar arteries in vitro that were induced by a wide range of substances implicated in the etiology of cerebral arterial spasm. Prostacyclin (10(-10) to 10(-6)M) caused a dose-related reversal of contractions induced by 5-hydroxytryptamine, noradrenaline, angiotensin II, prostaglandin (PG)F2 alpha, and U-46619 (a thromboxane-A2 mimetic). These agents were tested at concentrations or volumes that produced… CONTINUE READING
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