Prospects of boswellic acids as potential pharmaceutics.

@article{Du2015ProspectsOB,
  title={Prospects of boswellic acids as potential pharmaceutics.},
  author={Zhiyong Du and Zhenli Liu and Zhangchi Ning and Yuanyan Liu and Zhi-qian Song and Chun Wang and Aiping Lu},
  journal={Planta medica},
  year={2015},
  volume={81 4},
  pages={
          259-71
        }
}
Boswellic acids have long been considered the main bioactive components of frankincense, and many studies in vitro and in animals as well as several clinical studies have confirmed their various bioactivities. In particular, a large number of mechanistic studies have confirmed their anti-inflammatory and antitumor activities. However, not every boswellic acid exhibits a satisfactory pharmacological performance, which depends on the chemical structure and functional groups of the acid. To… Expand
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Metabolism of Boswellic Acids in Vitro and in Vivo
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This study indicates that the efficacy of B. serrata extract may be enhanced by increasing the bioavailability of AKBA, the main active ingredients of boswellic acids, which is not deacetylated to KBA. Expand
Boswellic acids: biological actions and molecular targets.
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This review summarizes the biological actions of BAs on the cellular and molecular level and attempts to put the data into perspective of the beneficial effects manifested in animal studies and trials with human subjects related to inflammation and cancer. Expand
On the interference of boswellic acids with 5-lipoxygenase: mechanistic studies in vitro and pharmacological relevance.
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The data show that boswellic acids are direct 5-LO inhibitors that efficiently suppress 5- LO product synthesis in common in vitro test models, however, the pharmacological relevance of such interference in vivo seems questionable. Expand
Boswellic acids from frankincense inhibit lipopolysaccharide functionality through direct molecular interference.
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It is concluded that structurally defined BAs are LPS inhibiting agents and it is suggested that β-BA may contribute to the observed anti-inflammatory effects of BSE during infections by suppressing LPS activity. Expand
Enhanced absorption of boswellic acids by a lecithin delivery form (Phytosome(®)) of Boswellia extract.
TLDR
The increased systemic availability of BAs and the improved tissue distribution, qualify Casperome™ for further clinical development to fully exploit the clinical potential of BE. Expand
Boswellia resin: from religious ceremonies to medical uses; a review of in-vitro, in-vivo and clinical trials.
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The pharmacology of Boswellia resin and of the small molecules identified as the active ingredients of the resin are reviewed, suggesting that incensole acetate and its derivatives are, at least in part, responsible for its anti-inflammatory effects. Expand
Modulation of Pgp function by boswellic acids.
TLDR
It was found that the Boswellia extract, as well as the keto-boswellic acids inhibit the transport activity of Pgp in the micromolecular range in both cell types, and no modulation was observed using those boswelli acids which have no keto group in their structure. Expand
Complexation with phosphatidyl choline as a strategy for absorption enhancement of boswellic acid
TLDR
The results of ex-vivo study show that BA-PC complex has significantly increased absorption compared with boswellic acid, when given in equimolar doses, and enhanced bioavailability and improved pharmacokinetics. Expand
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  • Chemistry, Medicine
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TLDR
Clinical studies suggest efficacy in some autoimmune diseases including rheumatoid arthritis, Crohn's disease, ulcerative colitis and bronchial asthma using Oleogum resins from BOSWELLIA species. Expand
Pharmacokinetic study of 11-Keto beta-Boswellic acid.
TLDR
Elimination half life of nearly six hours suggests that the drug needs to be given orally at the interval of six hours to achieve steady state, and BSE is a safe drug and well tolerated on oral administration. Expand
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