Prospects of Using of κ-Opioid Receptor Agonists U-50,488 and ICI 199,441 for Improving Heart Resistance to Ischemia/Reperfusion

@article{Tsibulnikov2015ProspectsOU,
  title={Prospects of Using of κ-Opioid Receptor Agonists U-50,488 and ICI 199,441 for Improving Heart Resistance to Ischemia/Reperfusion},
  author={S. Tsibulnikov and L. Maslov and A. V. Mukhomedzyanov and A. Krylatov and M. R. Tsibul’nikova and Y. Lishmanov},
  journal={Bulletin of Experimental Biology and Medicine},
  year={2015},
  volume={159},
  pages={718-721}
}
  • S. Tsibulnikov, L. Maslov, +3 authors Y. Lishmanov
  • Published 2015
  • Medicine
  • Bulletin of Experimental Biology and Medicine
  • We studied the ability of the agonist of κ1-opioid receptors U-50,488 in doses of 0.1 and 1 mg/kg to simulate ischemic pre- and postconditioning of the heart and κ-opioid receptors ICI 199,441 in a dose of 0.1 mg/kg to simulate the antiarrhythmic effect of heart preconditioning. The duration of ischemia was 10 or 45 min and the duration of reperfusion was 10 min or 2 h. Administration of 1 mg/kg U-50,488 both before ischemia and 5 min before reperfusion produced a pronounced antiarrhythmic… CONTINUE READING
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    References

    SHOWING 1-10 OF 15 REFERENCES
    Effect of Exogenous Kappa-Opioid Receptor Activation in Rat Model of Myocardial Infarction
    • 48
    Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning.
    • 1,989
    • PDF
    Sib. Med. Zh. (Tomsk)
    • Sib. Med. Zh. (Tomsk)
    • 2011
    Life Sci
    • Life Sci
    • 2009
    Basic Res. Cardiol
    • Basic Res. Cardiol
    • 2008