Prospects for worldwide tuberculosis control under the WHO DOTS strategy. Directly observed short-course therapy.

@article{Dye1998ProspectsFW,
  title={Prospects for worldwide tuberculosis control under the WHO DOTS strategy. Directly observed short-course therapy.},
  author={Charles Dye and Geoffrey P. Garnett and Katherine E Sleeman and Brian G. Williams},
  journal={Lancet},
  year={1998},
  volume={352 9144},
  pages={1886-91}
}
BACKGROUND WHO advocates the use of directly observed treatment with a short-course drug regimen as part of the DOTS strategy, but the potential effect of this strategy worldwide has not been investigated. METHODS We developed an age-structured mathematical model to explore the characteristics of tuberculosis control under DOTS, and to forecast the effect of improved case finding and cure on tuberculosis epidemics for each of the six WHO regions. FINDINGS In countries where the incidence of… CONTINUE READING
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