Prospects for vasculature reorganization in sentinel lymph nodes.

  title={Prospects for vasculature reorganization in sentinel lymph nodes.},
  author={Chao-nan Qian and James H. Resau and Bin Tean Teh},
  journal={Cell cycle},
  volume={6 5},
Primary tumors can induce vasculature and lymph channel reorganizations within sentinel lymph nodes before the arrival of cancer cells. The key blood vessels in such nodes that are remodeled are high endothelial venules (HEVs). The morphological alteration of HEVs in the presence of a cancer, coupled with the increased proliferation rate of the endothelial cells, results in a functional shifting of HEVs from immune response to blood-flow carrier. This tumor-induced reorganization is quite… CONTINUE READING

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 12 extracted citations

Changes in specialized blood vessels in lymph nodes and their role in cancer metastasis

Journal of Translational Medicine • 2012
View 6 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…