Prospects for vaccine protection against HIV-1 infection and AIDS.

  title={Prospects for vaccine protection against HIV-1 infection and AIDS.},
  author={Norman L. Letvin and Dan H Barouch and David C. Montefiori},
  journal={Annual review of immunology},
The rapid and devastating spread of the AIDS epidemic in the developing world as well as the difficulties associated with delivering antiretroviral drugs in affected countries underscore the urgent need for the development of a safe and effective AIDS vaccine. In this review, we discuss recent advances in our understanding of the cellular and humoral immune responses to human immunodeficiency virus type 1 (HIV-1) infection. We then describe vaccine strategies that have been explored and discuss… CONTINUE READING

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