Prospects for the diagnosis of breast cancer by noninvasive probing of calcifications using transmission Raman spectroscopy.

@article{Matousek2007ProspectsFT,
  title={Prospects for the diagnosis of breast cancer by noninvasive probing of calcifications using transmission Raman spectroscopy.},
  author={P. Matousek and N. Stone},
  journal={Journal of biomedical optics},
  year={2007},
  volume={12 2},
  pages={
          024008
        }
}
Breast calcifications can be found in both benign and malignant lesions, and the composition of these calcifications can indicate the possible disease state. As current practices such as mammography and histopathology examine the morphology of the specimen, they cannot reliably distinguish between the two types of calcification, which frequently are the only mammographic features that indicate the presence of a cancerous lesion. Raman spectroscopy is an optical technique capable of obtaining… Expand
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It is found that increase in carbonate intercalation in the hydroxyapatite lattice can be reliably employed to differentiate benign from malignant lesions, with algorithms based only on carbonate and cytoplasmic protein content exhibiting excellent negative predictive value. Expand
Rapid Differential Diagnosis of Breast Microcalcification Using Targeted Near-Infrared Fluorophores.
TLDR
Real-time near-infrared (NIR) fluorescence imaging of breast microcalcifications using targeted NIR fluorophores in combination with dual-channel NIR fluorescence Imaging system is reported and shows significant potential for breast cancer diagnosis and image-guided surgery performed with increased precision and efficiency. Expand
Diagnosing breast cancer using Raman spectroscopy: prospective analysis.
TLDR
The first prospective test of Raman spectroscopy in diagnosing normal, benign, and malignant human breast tissues is presented, with a sensitivity of 83%, a specificity of 93%, a positive predictive value of 36%, and a negative predictivevalue of 99% for distinguishing cancerous from normal and benign tissues. Expand
Relationships between pathology and crystal structure in breast calcifications: an in situ X-ray diffraction study in histological sections
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References

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