Prospects for the diagnosis of breast cancer by noninvasive probing of calcifications using transmission Raman spectroscopy.

@article{Matousek2007ProspectsFT,
  title={Prospects for the diagnosis of breast cancer by noninvasive probing of calcifications using transmission Raman spectroscopy.},
  author={P. Matousek and N. Stone},
  journal={Journal of biomedical optics},
  year={2007},
  volume={12 2},
  pages={
          024008
        }
}
Breast calcifications can be found in both benign and malignant lesions, and the composition of these calcifications can indicate the possible disease state. As current practices such as mammography and histopathology examine the morphology of the specimen, they cannot reliably distinguish between the two types of calcification, which frequently are the only mammographic features that indicate the presence of a cancerous lesion. Raman spectroscopy is an optical technique capable of obtaining… Expand
High sensitivity non-invasive detection of calcifications deep inside biological tissue using Transmission Raman Spectroscopy.
TLDR
A design of a new high performance deep Raman instrument is presented and its capability to detect type II calcifications (calcium hydroxyapatite) at clinically relevant concentrations and depths of around 40 mm in phantom tissue is demonstrated. Expand
Raman spectroscopy of breast tissues
TLDR
A Raman spectroscopic approach to metabolic fingerprinting in breast cancer detection and the recent developments in RamanSpectroscopic diagnosis of breast cancers are reviewed. Expand
Precision of Raman spectroscopy measurements in detection of microcalcifications in breast needle biopsies.
TLDR
The precision of Raman spectroscopy measurements in breast tissue obtained using a compact clinical Raman system is more than adequate to make accurate and repeatable predictions of microcalcifications in Breast tissue using decision algorithms based on model FC. Expand
Advanced transmission Raman spectroscopy: a promising tool for breast disease diagnosis.
TLDR
The method relies upon transmission Raman spectroscopy and permits the detailed characterization of the chemical composition of the probed volume and has shown significant potential for probing human breasts to provide complementary data in the early diagnosis of breast cancer. Expand
Characterisation of a novel transmission Raman spectroscopy platform for non-invasive detection of breast micro-calcifications
Our work focuses on the development of a medical Raman spectroscopy based platform to non-invasively detect and determine in-vivo molecular information deep inside biological tissues by monitoringExpand
Optical Spectroscopy: A Promising Diagnostic Tool for Breast Lesions
Background: With the rising trend of breast cancer, there is a need to develop a diagnostic procedure which can solve the problem of differentiating the benign and malignant lumps and of detectingExpand
Raman spectroscopic sensing of carbonate intercalation in breast microcalcifications at stereotactic biopsy
TLDR
It is found that increase in carbonate intercalation in the hydroxyapatite lattice can be reliably employed to differentiate benign from malignant lesions, with algorithms based only on carbonate and cytoplasmic protein content exhibiting excellent negative predictive value. Expand
Rapid Differential Diagnosis of Breast Microcalcification Using Targeted Near-Infrared Fluorophores.
TLDR
Real-time near-infrared (NIR) fluorescence imaging of breast microcalcifications using targeted NIR fluorophores in combination with dual-channel NIR fluorescence Imaging system is reported and shows significant potential for breast cancer diagnosis and image-guided surgery performed with increased precision and efficiency. Expand
Diagnosing breast cancer using Raman spectroscopy: prospective analysis.
TLDR
The first prospective test of Raman spectroscopy in diagnosing normal, benign, and malignant human breast tissues is presented, with a sensitivity of 83%, a specificity of 93%, a positive predictive value of 36%, and a negative predictivevalue of 99% for distinguishing cancerous from normal and benign tissues. Expand
Relationships between pathology and crystal structure in breast calcifications: an in situ X-ray diffraction study in histological sections
TLDR
It is discovered that these calcifications contain a small proportion of magnesium whitlockite, and that this proportion increases from benign to in situ to invasive cancer, and this suggests a mechanism explaining observations that carbonate levels within breast calcifications are lower in malignant specimens. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 43 REFERENCES
Depth profiling of calcifications in breast tissue using picosecond Kerr-gated Raman spectroscopy.
TLDR
It is demonstrated for the first time that Kerr-gated Raman spectroscopy is capable of non-destructive probing of sufficient biochemical information from calcifications buried within tissue, and this information can potentially be used as a first step in identifying the type of lesion. Expand
Subsurface probing of calcifications with spatially offset Raman spectroscopy (SORS): future possibilities for the diagnosis of breast cancer.
TLDR
SORS can be used to distinguish non-invasively between calcification types I and II within tissue of up to 10 mm deep, which secures the first step in taking this technique forward for clinical applications seeking to use Raman spectroscopy as an adjunct to mammography for early diagnosis of breast cancer. Expand
Raman spectroscopy for identification of epithelial cancers.
TLDR
The discussions outline the likely work required for successful implementation of in vivo Raman detection of early malignancies and the potential for Raman spectroscopy to achieve this goal is evaluated. Expand
Raman spectroscopy for the detection of cancers and precancers.
TLDR
Spectra obtained from intact tissues are comprehensively reviewed and discussed in terms of the molecular and microscopic literature to develop a framework for analyzing Raman signals to yield information about the molecular changes that occur with neoplasia. Expand
In vivo detection of dysplastic tissue by Raman spectroscopy.
TLDR
The potential of Raman spectroscopy for in vivo classification of normal and dysplastic tissue was investigated and a rat model was used, in which dysplasia in the epithelium of the palate was induced by topical application of the carcinogen 4-nitroquinoline 1-oxide. Expand
Identifying microcalcifications in benign and malignant breast lesions by probing differences in their chemical composition using Raman spectroscopy.
TLDR
It is believed that type II microcalcifications formed in benign ducts typically contain a larger amount of calcium carbonate and a smaller amount of protein than those formed in malignant ducts, which is a significant improvement over current X-ray mammography techniques, which are unable to reliably differentiate microCalcifications in benign and malignant breast lesions. Expand
Breast calcifications: analysis of imaging properties.
TLDR
Statistical differences between data from benign and malignant cases show the average distance between calcifications in malignant conditions was greater than in benign conditions, and tissue region averages surrounding calcifications associated with malign conditions were consistently higher than those for benign conditions. Expand
Near-infrared fluorescence imaging of microcalcification in an animal model of breast cancer.
TLDR
A simple and rapid animal model of focal calcification in breast cancer tumors has been developed and validated and the potential usefulness of the model for developing similar contrast agents for magnetic resonance and other imaging modalities is discussed. Expand
A new, non-destructive method for analysis of clinical samples with FT-IR microspectroscopy. Breast cancer tissue as an example.
A new method for infrared analysis of tissues and cells is presented. The method is based on Fourier transform infrared microspectroscopy coupled with attenuated total reflectance. The techniqueExpand
A new, non-destructive method for analysis of clinical samples with FT-IR microspectroscopy. Breast cancer tissue as an example.
TLDR
The method is based on Fourier transform infrared microspectroscopy coupled with attenuated total reflectance and allows spectroscopic measurements on the same samples used by pathologists for histopathological evaluation, e.g. stained samples on plain glass slides. Expand
...
1
2
3
4
5
...