Prospects for targeting the Bcl-2 family of proteins to develop novel cytotoxic drugs.

@article{Baell2002ProspectsFT,
  title={Prospects for targeting the Bcl-2 family of proteins to develop novel cytotoxic drugs.},
  author={Jonathan B. Baell and David Ching Siang Huang},
  journal={Biochemical pharmacology},
  year={2002},
  volume={64 5-6},
  pages={
          851-63
        }
}
Over the last decade the molecular mechanisms controlling programmed cell death (apoptosis) have become clearer. It appears that many physiological and damage signals activate the cell death machinery by inhibiting the pro-survival Bcl-2 proteins. Since many chemotherapeutic drugs used to treat cancers activate the cell death machinery indirectly, there is much interest in developing peptide and non-peptide mimics of the BH3-only proteins, a family of proteins that act as direct antagonists of… CONTINUE READING
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