Prospects for antiviral ribozymes and deoxyribozymes.

@article{Peracchi2004ProspectsFA,
  title={Prospects for antiviral ribozymes and deoxyribozymes.},
  author={Alessio Peracchi},
  journal={Reviews in medical virology},
  year={2004},
  volume={14 1},
  pages={47-64}
}
Ribozymes and deoxyribozymes (collectively referred to as nucleic acid enzymes) can be designed to cleave substrate mRNAs in a sequence-specific manner, and thus represent a potentially important tool to inhibit selectively the expression of deleterious genes. Nucleic acid enzymes can be delivered to cells either as genes encoding RNA enzymes (ribozymes), or exogenously as in vitro produced agents. This review focuses in particular on the 'exogenous application' of ribozymes and deoxyribozymes… CONTINUE READING

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