Prospective study of estrogen replacement therapy and risk of breast cancer in postmenopausal women.

@article{Colditz1990ProspectiveSO,
  title={Prospective study of estrogen replacement therapy and risk of breast cancer in postmenopausal women.},
  author={Graham A. Colditz and Meir Jonathan Stampfer and Walter C Willett and Charles H. Hennekens and Bernard A Rosner and Frank E. Speizer},
  journal={JAMA},
  year={1990},
  volume={264 20},
  pages={2648-53}
}
We prospectively examined the use of estrogen replacement therapy in relation to breast cancer incidence in a cohort of women 30 to 55 years of age in 1976. During 367 187 person-years of follow-up among postmenopausal women, 722 incident cases of breast cancer were documented. Overall, past users of replacement estrogen were not at increased risk (relative risk, 0.98; 95% confidence interval, 0.81 to 1.18), including even those with more than 10 years since last [corrected] use (relative risk… CONTINUE READING

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