Prospective screening for pediatric mitochondrial trifunctional protein defects in pregnancies complicated by liver disease.

@article{Yang2002ProspectiveSF,
  title={Prospective screening for pediatric mitochondrial trifunctional protein defects in pregnancies complicated by liver disease.},
  author={Zi Yang and J. Yamada and Yiwen Zhao and A. Strauss and J. Ibdah},
  journal={JAMA},
  year={2002},
  volume={288 17},
  pages={
          2163-6
        }
}
CONTEXT Acute fatty liver of pregnancy (AFLP) and hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome are serious complications of pregnancy. Studies in families with recessively inherited mitochondrial trifunctional protein defects documented an association between these maternal illnesses and fetal deficiency of long-chain 3-hydroxyacyl coenzyme A dehydrogenase; this enzyme resides in the alpha subunit of the trifunctional protein and catalyzes the third step in long-chain… Expand
109 Citations
Maternal heterozygosity for a mitochondrial trifunctional protein mutation as a cause for liver disease in pregnancy.
[Acute fatty liver in pregnancy: revealing fetal fatty acid oxidation disorders].
[Long chain 3-hydroxyacyl-coA dehydrogenase deficiency, association with HELLP and magnetic resonance spectroscopy findings].
HELLP Syndrome
Role of 3-Hydroxy Fatty Acid-Induced Hepatic Lipotoxicity in Acute Fatty Liver of Pregnancy
Acute fatty liver of pregnancy and neonatal long-chain 3-hydroxyacyl-coenzyme A dehydrogenase (LCHAD) deficiency
Differentiation of acute fatty liver of pregnancy from syndrome of hemolysis, elevated liver enzymes and low platelet counts
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 27 REFERENCES
The molecular basis of pediatric long chain 3-hydroxyacyl-CoA dehydrogenase deficiency associated with maternal acute fatty liver of pregnancy.
The HELLP syndrome associated with fetal medium-chain acyl-CoA dehydrogenase deficiency
...
1
2
3
...