Prospective multicenter cohort study of estrogen and insulin-like growth factor system in BRCA mutation carriers

@article{Kim2015ProspectiveMC,
  title={Prospective multicenter cohort study of estrogen and insulin-like growth factor system in BRCA mutation carriers},
  author={Jayeon Kim and Lauren Keller Johnson and C{\'e}cile Skrzynia and Ashley K Buchanan and Clarisa Gracia and Jennifer E. Mersereau},
  journal={Cancer Causes & Control},
  year={2015},
  volume={26},
  pages={1087-1092}
}
Major clinical characteristics of BRCA1/2-related cancers include association with estrogen and metabolic consequences. We aimed to evaluate serum estradiol (E2) and insulin-like growth factor 1 (IGF-1) levels as a marker of insulin resistance in BRCA1/2 mutation carriers and high-risk, BRCA-negative controls. Eligible cancer-free women (age 18–42 with regular menstrual cycles) who had been screened for BRCA1/2 mutations between 2005 and 2013 completed a questionnaire and underwent a single… CONTINUE READING

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