Prospective evaluation of the thrombotic risk in children with acute lymphoblastic leukemia carrying the MTHFR TT 677 genotype, the prothrombin G20210A variant, and further prothrombotic risk factors.

@article{NowakGttl1999ProspectiveEO,
  title={Prospective evaluation of the thrombotic risk in children with acute lymphoblastic leukemia carrying the MTHFR TT 677 genotype, the prothrombin G20210A variant, and further prothrombotic risk factors.},
  author={Ulrike Nowak-G{\"o}ttl and Cornelia Wermes and Ralf Junker and H. G. Koch and Rosmarie Schobess and Gudrun Fleischhack and Dirk Schwabe and Silke Ehrenforth},
  journal={Blood},
  year={1999},
  volume={93 5},
  pages={1595-9}
}
The reported incidence of thromboembolism in children with acute lymphoblastic leukemia (ALL) treated with L-asparaginase, vincristine, and prednisone varies from 2.4% to 11.5%. The present study was designed to prospectively evaluate the role of the TT677 methylenetetrahydrofolate reductase (MTHFR) genotype, the prothrombin G20210A mutation, the factor V G1691A mutation, deficiencies of protein C, protein S, antithrombin, and increased lipoprotein (a) concentrations in leukemic children… CONTINUE READING

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