Prospective evaluation of the risk conferred by factor V Leiden and thermolabile methylenetetrahydrofolate reductase polymorphisms in pregnancy.

@article{Murphy2000ProspectiveEO,
  title={Prospective evaluation of the risk conferred by factor V Leiden and thermolabile methylenetetrahydrofolate reductase polymorphisms in pregnancy.},
  author={Raymond P.J. Murphy and Colleen Donoghue and R J Nallen and Michelle D'Mello and Carmen L Regan and Alexander S. Whitehead and Desmond J. Fitzgerald},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2000},
  volume={20 1},
  pages={266-70}
}
Factor V (FV) Leiden and thermolabile methylenetetrahydrofolate reductase (MTHFR) are 2 common polymorphisms that have been implicated in vascular thrombosis. We determined whether these mutations predicted an adverse outcome in pregnancy. Second, we looked for an interaction between these 2 mutations in patients with recurrent fetal loss or thrombosis in pregnancy. Primigravid subjects at their booking visit to the National Maternity Hospital (Holles Street, Dublin, Ireland) were screened for… CONTINUE READING

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