Prospective evaluation of the effect of an aminoglycoside dosing regimen on rates of observed nephrotoxicity and ototoxicity.

@article{Rybak1999ProspectiveEO,
  title={Prospective evaluation of the effect of an aminoglycoside dosing regimen on rates of observed nephrotoxicity and ototoxicity.},
  author={Michael Joseph Rybak and B J Abate and Sanghee L Kang and Margie J Ruffing and Stephen A. Lerner and G L Drusano},
  journal={Antimicrobial agents and chemotherapy},
  year={1999},
  volume={43 7},
  pages={1549-55}
}
The nephrotoxicity and ototoxicity associated with once-daily versus twice-daily administration of aminoglycosides was assessed in patients with suspected or proven gram-negative bacterial infections in a randomized, double-blind clinical trial. Patients who received therapy for >/=72 h were evaluated for toxicity. Patients also received concomitant antibiotics as deemed necessary for treatment of their infection. Plasma aminoglycoside concentrations, prospective aminoglycoside dosage… CONTINUE READING

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