Prospective evaluation of molecular screening for Lynch syndrome in patients with endometrial cancer ≤ 70 years.

@article{Leenen2012ProspectiveEO,
  title={Prospective evaluation of molecular screening for Lynch syndrome in patients with endometrial cancer ≤ 70 years.},
  author={Celine H M Leenen and Margot G F van Lier and Helena C van Doorn and Monique Esther van Leerdam and Sjarlot GS Kooi and Judith de Waard and Robert F. Hoedemaeker and Ans M. W. van den Ouweland and Sanne M Hulspas and Hendrikus Jan Dubbink and Ernst J Kuipers and Anja Wagner and Winand N. M. Dinjens and Ewout Willem Steyerberg},
  journal={Gynecologic oncology},
  year={2012},
  volume={125 2},
  pages={414-20}
}
OBJECTIVE Lynch syndrome (LS) is a hereditary syndrome that predisposes to multiple malignancies including endometrial cancer (EC). We aimed to evaluate a diagnostic strategy for LS based on routine analysis of microsatellite instability (MSI) and immunohistochemical (IHC) staining for mismatch repair (MMR) proteins in tumour tissue of all newly diagnosed EC patients ≤ 70 years. METHODS Consecutive EC patients ≤ 70 years were included prospectively in eight Dutch centres. EC specimens were… CONTINUE READING
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A review on the molecular diagnostics of Lynch syndrome: a central role for the pathology laboratory

  • MG van Lier, A Wagner, ME van Leerdam, K Biermann, EJ Kuipers, EW Steyerberg
  • J Cell Mol Med
  • 2010
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