Prospective evaluation of a model of prediction of invasive bacterial infection risk among children with cancer, fever, and neutropenia.

Abstract

A risk prediction model for invasive bacterial infection (IBI) was prospectively evaluated among children presenting with cancer, fever, and neutropenia. The model incorporated assessment of 5 previously identified risk factors: serum level of C-reactive protein (CRP) >/=90 mg/L, hypotension, identification of relapse of leukemia as the cancer type, platelet count of </=50,000 platelets/mm(3), and recent receipt of chemotherapy [16]. Children were uniformly evaluated at enrollment and were classified as having high or low risk for IBI according to a model that considers the number and type of variables present. Of the 263 febrile episodes evaluated during a 17-month period, 140 (53%) were in IBI-positive children. The sensitivity, specificity, and positive and negative predictive values of the model were 92%, 76%, 82%, and 90%, respectively. Identification of these 5 risk factors during the first 24 h of hospitalization was helpful in discriminating between children with a high or low risk for IBI.

2 Figures and Tables

050100'04'06'08'10'12'14'16
Citations per Year

438 Citations

Semantic Scholar estimates that this publication has 438 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Santolaya2002ProspectiveEO, title={Prospective evaluation of a model of prediction of invasive bacterial infection risk among children with cancer, fever, and neutropenia.}, author={M E Santolaya and A M Alvarez and C L Avil{\'e}s and A Becker and J Cofr{\'e} and N Enr{\'i}quez and M O'Ryan and E Pay{\'a} and C Salgado and P Silva and J Tordecilla and M Varas and M Villarroel and T Viviani and M Zubieta}, journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America}, year={2002}, volume={35 6}, pages={678-83} }