Prospective evaluation of PF4/heparin immunoassays for the diagnosis of heparin-induced thrombocytopenia.

@article{Bakchoul2009ProspectiveEO,
  title={Prospective evaluation of PF4/heparin immunoassays for the diagnosis of heparin-induced thrombocytopenia.},
  author={Tamam Bakchoul and Astrid Giptner and Abderrahim Najaoui and G. Bein and Sentot Santoso and Ulrich Sachs},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2009},
  volume={7 8},
  pages={1260-5}
}
BACKGROUND Heparin-induced thrombocytopenia (HIT) is an adverse complication of heparin caused by HIT antibodies that recognize platelet factor 4-heparin (PF4/hep) complexes leading to platelet activation. Several methods are available for the identification of HIT antibodies. OBJECTIVES To evaluate the clinical usefulness of different antigen-binding assays for detection of antibodies against PF4/hep complexes in a prospective study. PATIENTS/METHODS A prospective cohort of 500 surgical… CONTINUE READING