Prospective endoscopic study of stress erosions and ulcers in critically ill neurosurgical patients: current incidence and effect of acid-reducing prophylaxis.

@article{Reusser1990ProspectiveES,
  title={Prospective endoscopic study of stress erosions and ulcers in critically ill neurosurgical patients: current incidence and effect of acid-reducing prophylaxis.},
  author={Pierre Reusser and Klaus Gyr and Doris Scheidegger and Beat Buchmann and Mauro Buser and Werner Zimmerli},
  journal={Critical care medicine},
  year={1990},
  volume={18 3},
  pages={270-4}
}
We studied prospectively 40 critically ill neurosurgical patients who required prolonged mechanical ventilation to determine the current incidence of stress-related gastroduodenal erosions and ulcers, and to assess endoscopically the efficacy of acid-reducing prophylactic treatment. Nineteen patients were randomized to receive ranitidine plus antacids if necessary to maintain gastric pH at greater than or equal to 4. The remaining 21 patients were given no drug prophylaxis. Gastric pH was… CONTINUE READING