Prospective determination of prevalence of lynch syndrome in young women with endometrial cancer.

@article{Lu2007ProspectiveDO,
  title={Prospective determination of prevalence of lynch syndrome in young women with endometrial cancer.},
  author={Karen H. Lu and John Schorge and Kerry J Rodabaugh and Molly Daniels and Charlotte C. Sun and Pamela T Soliman and Kristin G White and Rajyalakshmi Luthra and David M. Gershenson and Russell R. Broaddus},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2007},
  volume={25 33},
  pages={5158-64}
}
PURPOSE Age younger than 50 years at the time of colon cancer diagnosis is often used as a screening criterion for Lynch syndrome (hereditary nonpolyposis colorectal cancer syndrome). The purpose of this study was to determine the prevalence of MLH1, MSH2, and MSH6 mutations in an unselected cohort of women diagnosed with endometrial cancer at age younger than 50 years. METHODS A prospective, multicenter study was performed at three institutions. After written consent was obtained, germline… CONTINUE READING

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