Prospective comparison of prognostic scores in palliative care cancer populations.

Abstract

PURPOSE Predicting prognosis in advanced cancer aids physicians in clinical decision making and can help patients and their families to prepare for the time ahead. MATERIALS AND METHODS This multicenter, observational, prospective, nonrandomized population-based study evaluated life span prediction of four prognostic scores used in palliative care: the original palliative prognostic score (PaP Score), a variant of PaP Score including delirium (D-PaP Score), the Palliative Performance Scale, and the Palliative Prognostic Index. RESULTS A total of 549 patients were enrolled onto the study. Median survival of the entire group was 22 days (95% confidence intervals [95% CI] = 19-24). All four prognostic models discriminated well between groups of patients with different survival probabilities. Log-rank tests were all highly significant (p < .0001). The PaP and D-PaP scores were the most accurate, with a C index of 0.72 (95% CI = 0.70-0.73) and 0.73 (95% CI = 0.71-0.74), respectively. CONCLUSION It can be confirmed that all four prognostic scores used in palliative care studies accurately identify classes of patients with different survival probabilities. The PaP Score has been extensively validated and shows high accuracy and reproducibility in different settings.

DOI: 10.1634/theoncologist.2011-0397
0100200201220132014201520162017
Citations per Year

369 Citations

Semantic Scholar estimates that this publication has 369 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Maltoni2012ProspectiveCO, title={Prospective comparison of prognostic scores in palliative care cancer populations.}, author={Marco Maltoni and Emanuela Scarpi and Cristina Pittureri and Francesca Martini and Luigi Montanari and Elena Amaducci and Stefania Derni and Laura Fabbri and Marta Rosati and Dino Amadori and Oriana Nanni}, journal={The oncologist}, year={2012}, volume={17 3}, pages={446-54} }