Prospective cohort study of antioxidant vitamin supplement use and the risk of age-related maculopathy.

@article{Christen1999ProspectiveCS,
  title={Prospective cohort study of antioxidant vitamin supplement use and the risk of age-related maculopathy.},
  author={William G Christen and Umed Ajani and Robert J. Glynn and JoAnn E. Manson and Debra A. Schaumberg and E C Chew and Julie E. Buring and Charles H. Hennekens},
  journal={American journal of epidemiology},
  year={1999},
  volume={149 5},
  pages={
          476-84
        }
}
In a prospective cohort study, the authors examined whether self-selection for antioxidant vitamin supplement use affects the incidence of age-related maculopathy. The study population consisted of 21,120 US male physician participants in the Physicians' Health Study I who did not have a diagnosis of age-related maculopathy at baseline (1982). During an average of 12.5 person-years of follow-up, a total of 279 incident cases of age-related maculopathy with vision loss to 20/30 or worse were… 
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It may not be prudent to prescribe antioxidants and micronutrients without a proper assessment of the individual’s health and dietary status, and these supplements should not be prescribed just for the purpose of providing patients some kind of therapy, which may give a false sense of mental satisfaction.
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The science behind the nutritional factors included in these interventional studies and the reasons for considering their inclusion to lower the rate of AMD progression are examined.
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The evidence that lifetime oxidative stress plays an important role in the development of ARM is now compelling and the positive outcomes in the Age-Related Eye Diseases Study have given hope that modulation of the antioxidant balance through supplementation can help prevent progression of ARM to AMD.
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