Prospective application of a multiplex reverse transcription-polymerase chain reaction assay for the detection of balanced translocations in leukaemia: a single-laboratory study of 390 paediatric and adult patients.

@article{Olesen2004ProspectiveAO,
  title={Prospective application of a multiplex reverse transcription-polymerase chain reaction assay for the detection of balanced translocations in leukaemia: a single-laboratory study of 390 paediatric and adult patients.},
  author={Lene Hyldahl Olesen and Niels Clausen and Andreja Dimitrijevic and Gitte Kerndrup and Eigil Kjeldsen and Peter Hokland},
  journal={British journal of haematology},
  year={2004},
  volume={127 1},
  pages={59-66}
}
The upfront application of molecular methods for identifying the fusion transcripts arising from balanced translocations in haematopoietic malignancies has several advantages: sensitivity is independent of its frequency, i.e. rare ones are not missed, cytogenetically cryptic aberrations are identified and it provides a platform for minimal residual disease (MRD) detection. Employing a multiplex reverse transcription polymerase chain reaction (RT-PCR) assay identifying 27 fusion transcripts we… CONTINUE READING
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