Prospective acetylcholinesterase inhibitory activity of indole and its analogs.

@article{Khorana2012ProspectiveAI,
  title={Prospective acetylcholinesterase inhibitory activity of indole and its analogs.},
  author={N. Khorana and Kanokwan Changwichit and K. Ingkaninan and M. Utsintong},
  journal={Bioorganic \& medicinal chemistry letters},
  year={2012},
  volume={22 8},
  pages={
          2885-8
        }
}
Acetylcholinesterase (AChE) inhibitory activity is one of the proposed targets for indole analogs. Simple indoles with substitution of methoxy, carboxy or hydroxy at the benzene ring showed a low percent of inhibitory activity in eel-AChE. Adding a side chain at the pyrrole ring, such as serotonin, β-carbolines and quinolines (the bioisostere of indole), improved the inhibitory activity significantly. However, proper substitution and conformation of the ring were required for good binding. The… Expand
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