Prospective Validation of a 21-Gene Expression Assay in Breast Cancer.

  title={Prospective Validation of a 21-Gene Expression Assay in Breast Cancer.},
  author={Joseph A Sparano and Robert J. Gray and Della F Makower and Kathleen I. Pritchard and Kathy S. Albain and Daniel F. Hayes and Charles Edward Geyer and Elizabeth Claire Dees and Edith A. Perez and John P. Olson and Jo Anne Zujewski and Tracy G. Lively and Sunil S Badve and Thomas James Saphner and Lynne I Wagner and T. Whelan and Matthew J. Ellis and Soonmyung Paik and William C. Wood and Peter Marcus Ravdin and Maccon M. Keane and Henry L Gomez Moreno and P. Sarweswar Reddy and Timothy F Goggins and Ingrid A. Mayer and Adam M. Brufsky and Deborah Lynn Toppmeyer and Virginia G. Kaklamani and James Norman Atkins and Jeffrey L. Berenberg and George W. Sledge},
  journal={The New England journal of medicine},
  volume={373 21},
BACKGROUND Prior studies with the use of a prospective-retrospective design including archival tumor samples have shown that gene-expression assays provide clinically useful prognostic information. However, a prospectively conducted study in a uniformly treated population provides the highest level of evidence supporting the clinical validity and usefulness of a biomarker. METHODS We performed a prospective trial involving women with hormone-receptor-positive, human epidermal growth factor… CONTINUE READING
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