Prospective Randomized Study on the Efficacy of Blue Light in the Treatment of Psoriasis Vulgaris

@article{Weinstabl2011ProspectiveRS,
  title={Prospective Randomized Study on the Efficacy of Blue Light in the Treatment of Psoriasis Vulgaris},
  author={Antonia Weinstabl and Susanne Hoff-Lesch and Hans Friedrich Merk and Verena von Felbert},
  journal={Dermatology},
  year={2011},
  volume={223},
  pages={251 - 259}
}
Background:Blue light has no known toxic effects on human skin, but reduces the proliferative capacity of keratinocytes in vitro. We therefore investigated the efficacy of blue light in the treatment of psoriasis vulgaris (PV). Methods: Forty patients with mild to moderate PV and bilateral plaques were assigned to two groups. Group 1 (n = 20) received irradiation at home with blue light (light-emitting diode, LED, emission maximum: 420 nm) once daily for 4 weeks. In parallel, group 2 (n = 20… 

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References

SHOWING 1-10 OF 24 REFERENCES
Repeated exposure to blue light does not improve psoriasis.
TLDR
Repeated exposure toblue light did not improve psoriasis and a single exposure to blue light induced almost complete photobleaching of PpIX.
Effect of blue light on the proliferation of human gingival fibroblasts.
Guidelines for topical photodynamic therapy: update
Multicentre randomized controlled studies now demonstrate high efficacy of topical photodynamic therapy (PDT) for actinic keratoses, Bowen’s disease (BD) and superficial basal cell carcinoma (BCC),
Blue-light irradiation regulates proliferation and differentiation in human skin cells.
TLDR
It is found that light at wavelengths of 632-940 nm has no effect, but irradiation with blue light at 412-426 nm exerts toxic effects at high fluences, which provides evidence for a molecular mechanism by which blue light may be effective in treating hyperproliferative skin conditions by reducing proliferation due to the induction of differentiation.
Efficacy of blue light vs. red light in the treatment of psoriasis: a double‐blind, randomized comparative study
TLDR
Protoporphyrin IX is present in psoriatic skin without the preceding application of aminolevulinic acid and is a potential target for photodynamic treatment with high‐dose visible light.
Photodynamic Therapy in the Treatment of Actinic Keratosis †
TLDR
The efficacy and the low risk of side effects of PDT have resulted in a high patient preference in clinical trials and the value of PDT in comparison with cryotherapy or 5‐fluorouracil is discussed.
Ultraviolet A1 phototherapy for treatment of acrosclerosis in systemic sclerosis: controlled study with half‐side comparison analysis
TLDR
Recent studies appear to indicate the interest of UVA1 in acrosclerosis for patients with SS, however, these studies are uncontrolled.
Pretreatment to Enhance Protoporphyrin IX Accumulation in Photodynamic Therapy
TLDR
Simple pretreatments or additions to the regular practice of PDT, aimed to optimize intralesional PpIX content, improve the clinical outcome.
Intralesional Photodynamic Therapy: A Comment on ‘Pretreatment to Enhance Protoporphyrin IX Accumulation in Photodynamic Therapy’ by Gerritsen et al.
TLDR
Performing intralesional PDT is less time-consuming than several other pretreatment procedures and the time necessary to allow the conversion of the prodrug into the final photosensitizer is likely to be much shorter, as incubations.
[Cataract extraction and blue light--impact on the retina].
TLDR
This review focuses on the scientific background for the use of "yellow artificial lenses" and can show that many studies in cell and molecular biology, animal experiments and first clinical trials point to a preferential use of yellow-tinted lenses especially in the elderly and AMD patients.
...
1
2
3
...