Prospective Randomized Long-Term Study on the Efficacy and Safety of UV-Free Blue Light for Treating Mild Psoriasis Vulgaris

@article{Pfaff2015ProspectiveRL,
  title={Prospective Randomized Long-Term Study on the Efficacy and Safety of UV-Free Blue Light for Treating Mild Psoriasis Vulgaris},
  author={Stephanie Pfaff and J{\"o}rg Liebmann and Matthias Born and Hans Friedrich Merk and Verena von Felbert},
  journal={Dermatology},
  year={2015},
  volume={231},
  pages={24 - 34}
}
Background: Blue light irradiation reduces the proliferation of keratinocytes and modulates T-cell immune response in vitro and has been shown to reduce the severity of psoriasis vulgaris (Pv) in two clinical trials. Objective: Evaluation of safety and efficacy of long-term UV-free blue light treatment at home for mild Pv. Methods: Forty-seven patients with mild Pv were randomized for receiving high-intensity blue light treatment (HI: 453 nm LED, 200 mW/cm2, n = 24) and low-intensity treatment… 

Figures and Tables from this paper

Prospective, Randomized Study on the Efficacy and Safety of Local UV-Free Blue Light Treatment of Eczema
TLDR
UV-free blue light was safe and effective in the reduction of eczema lesions and the primary end point change from baseline in the mean sum score of the local Eczema Severity Index was more pronounced for the treated area than for the control area.
Prospective 3-month study on the efficacy of UV-free blue light in mild psoriasis vulgaris treatment
TLDR
The results confirm that phototherapy using blue LED light is both a safe and highly effective way to treat psoriasis.
Treatment of Atopic Dermatitis Using a Full-Body Blue Light Device (AD-Blue): Protocol of a Randomized Controlled Trial
TLDR
A multicenter, placebo-controlled, double-blinded, 3-armed, prospective, randomized controlled trial to investigate the efficacy and safety of full-body blue light devices compared with that of placebo irradiation for the treatment of atopic dermatitis.
Treatment of Atopic Dermatitis Using a Full-Body Blue Light Device (AD-Blue): Protocol of a Randomized Controlled Trial (Preprint)
TLDR
A multicenter, placebo-controlled, double-blinded, 3-armed, prospective, randomized controlled trial to investigate the efficacy and safety of full-body blue light devices compared with that of placebo irradiation for the treatment of atopic dermatitis.
The cost-effectiveness of blue-light therapy in the treatment of mild-to-moderate psoriasis.
TLDR
Treatment of mild-to-moderate chronic plaque psoriasis using blue-light therapy may be more cost-effective than TCF.
Efficacy of blue light vs. fluocinolone 0.025% ointment in treatment of localized plaque psoriasis
TLDR
This study aimed to assess the efficacy of blue light treatment in plaque psoriasis in comparison to fluocinolone 0.025% ointment (topical steroid) in the same patients.
A Dynamic Model for Prediction of Psoriasis Management by Blue Light Irradiation
TLDR
Simulations indicate that high efficacy is achieved by regimes with long duration and high fluence levels, regardless of the chosen intensity, and constitute a framework for testing diverse hypotheses on the underlying mechanism of blue light-based phototherapy, and for designing effective strategies for the treatment of psoriasis.
A clinical review of phototherapy for psoriasis
TLDR
UV light is primarily for stable plaque psoriasis and PDL for topical psoriatic lesions with small area, both of which are safe and effective, and PUVA has better curative effects than UVB for managing refractory Psoriasis plaques, if its side effects can be better controlled.
Advances in phototherapy for psoriasis and atopic dermatitis
TLDR
This review provides an update on the different forms of phototherapy used for the treatment of psoriasis and atopic dermatitis, including the immunosuppressive effect of UV light, the anti-inflammatory effect of vascular lasers and the LLLT induced photobiomodulation.
Blue Light in Dermatology
TLDR
It was demonstrated that blue light induces an anti-inflammatory and antiproliferative effect; thus, it may be beneficial for hyperproliferative and chronic inflammatory skin diseases such as atopic dermatitis, eczema, and psoriasis and long-term safety should be monitored.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 28 REFERENCES
Prospective Randomized Study on the Efficacy of Blue Light in the Treatment of Psoriasis Vulgaris
TLDR
Blue light appears to be a promising treatment modality in PV that warrants further evaluation in larger studies, and plaque status as assessed by both the physicians and the patients improved continuously during the 4 weeks of treatment and steadily declined thereafter.
Clinical Efficacy of Blue Light Full Body Irradiation as Treatment Option for Severe Atopic Dermatitis
TLDR
Blue light-irradiation may represent a suitable treatment option for AD providing long term control of disease, and immunohistochemistry of skin biopsies obtained at baseline and after 5 and 15 days revealed that, unlike UV light, blue light-treatment did not induce Langerhans cell or T cell depletion from skin.
Combination blue (415 nm) and red (633 nm) LED phototherapy in the treatment of mild to severe acne vulgaris
  • D. Goldberg, B. A. Russell
  • Medicine
    Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology
  • 2006
TLDR
Combination blue and red LED therapy appears to have excellent potential in the treatment of mild to severe acne and treatment appears to be both pain‐ and side effect‐free.
Repeated exposure to blue light does not improve psoriasis.
TLDR
Repeated exposure toblue light did not improve psoriasis and a single exposure to blue light induced almost complete photobleaching of PpIX.
Severe psoriasis--oral therapy with a new retinoid.
TLDR
Ro 10--9359 proved to be an extremely potent antipsoriatic drug and a more than 90% reduction of psoriatic lesions could be seen in 10 patients out of 20 after 4-8 weeks of treatment.
A review of phototherapy protocols for psoriasis treatment.
Blue light irradiation suppresses dendritic cells activation in vitro
TLDR
It is reported that irradiation neither induced apoptosis nor maturation of monocyte‐derived and myeloid DC, and subsequent DC maturation upon LPS/IFNγ stimulation was impaired in a dose‐dependent manner as assessed by maturation markers and cytokine release.
Dupilumab treatment in adults with moderate-to-severe atopic dermatitis.
TLDR
Patients treated with dupilumab had marked and rapid improvement in all the evaluated measures of atopic dermatitis disease activity, and side-effect profiles were not dose-limiting.
Blue-light irradiation regulates proliferation and differentiation in human skin cells.
TLDR
It is found that light at wavelengths of 632-940 nm has no effect, but irradiation with blue light at 412-426 nm exerts toxic effects at high fluences, which provides evidence for a molecular mechanism by which blue light may be effective in treating hyperproliferative skin conditions by reducing proliferation due to the induction of differentiation.
...
1
2
3
...