Prospective QSAR-Based Prediction Models with Pharmacophore Studies of Oxadiazole-Substituted $$\alpha$$ α -Isopropoxy Phenylpropanoic Acids with Dual Activators of PPAR $$\alpha$$ α and PPAR $$\gamma$$ γ

  • Mukesh C. Sharma
  • Published 2015 in
    Interdisciplinary Sciences: Computational Life…

Abstract

A series of oxadiazole-substituted $$\alpha$$ α -isopropoxy phenylpropanoic acids with dual activators of PPAR $$\alpha$$ α and PPAR $$\gamma$$ γ derivatives were subjected to two-dimensional and k-Nearest Neighbors molecular field analysis. The statistically significant best 2D-QSAR (PPAR $$\alpha$$ α ) model having good predictive ability with statistical… (More)
DOI: 10.1007/s12539-015-0009-y

6 Figures and Tables

Topics

  • Presentations referencing similar topics