Prospective, randomized trial of intravenous versus intraperitoneal 5-fluorouracil in patients with advanced primary colon or rectal cancer.

@article{Sugarbaker1985ProspectiveRT,
  title={Prospective, randomized trial of intravenous versus intraperitoneal 5-fluorouracil in patients with advanced primary colon or rectal cancer.},
  author={Paul H Sugarbaker and F J Gianola and James Speyer and Robert C. Wesley and Ivan Barofsky and Charles E. Meyers},
  journal={Surgery},
  year={1985},
  volume={98 3},
  pages={414-22}
}
No new chemotherapy agents have been developed recently that present hope for improving survival in patients with colon or rectal cancer. We undertook this study to investigate a new route of administering an old drug, 5-fluorouracil (5-FU). Sixty-six patients with advanced primary colon or rectal cancer were randomized to receive 12 cycles with increasing dosages of intravenous (IV) or intraperitoneal (IP) 5-FU; the mean follow-up time was three years. The maximal tolerable dose and objective… CONTINUE READING
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