Prospective, population-based long QT molecular autopsy study of postmortem negative sudden death in 1 to 40 year olds.

@article{Skinner2011ProspectivePL,
  title={Prospective, population-based long QT molecular autopsy study of postmortem negative sudden death in 1 to 40 year olds.},
  author={Jonathan R Skinner and Jackie Robyn Crawford and Warren H. Smith and Andrew Aitken and David Heaven and C. Evans and Ian S. Hayes and Katherine R Neas and Simon Robert Stables and Timothy D Koelmeyer and Lloyd Denmark and Jane Vuletic and Fraser Maxwell and Kate White and Tao Yang and Dan M. Roden and Trond P. Leren and Andrew N Shelling and Donald R. Love},
  journal={Heart rhythm},
  year={2011},
  volume={8 3},
  pages={412-9}
}
BACKGROUND Retrospective investigation of sudden unexplained death in the young (SUDY) reveals that a high proportion is due to inherited heart disease. OBJECTIVE The purpose of this study was to ascertain the diagnostic value of postmortem long QT (LQT) genetic analysis in a prospective study of SUDY victims 1-40 years old. METHODS Denaturing high-performance liquid chromatography or direct sequencing of LQT genes 1, 2, 3, 5, and 6 was performed, in a National New Zealand protocol, in SUDY… CONTINUE READING
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