Prospective, pilot, open-label, short-term study of conversion to leflunomide reverses chronic renal allograft dysfunction.

Leflunomide (LEF) is a synthetic isoxazole derivative with anti-inflammatory and antiviral properties, which has been reported to prevent acute rejection and delay progression of chronic allograft nephropathy (CAN) in animal models. We performed a pilot, crossover trial in 22 renal transplant recipients who were converted from azathioprine (AZA) or… CONTINUE READING