Prospective, Randomized Study on the Efficacy and Safety of Local UV-Free Blue Light Treatment of Eczema

@article{Keemss2016ProspectiveRS,
  title={Prospective, Randomized Study on the Efficacy and Safety of Local UV-Free Blue Light Treatment of Eczema},
  author={Kim Keemss and Stephanie Pfaff and Matthias Born and J{\"o}rg Liebmann and Hans Friedrich Merk and Verena von Felbert},
  journal={Dermatology},
  year={2016},
  volume={232},
  pages={496 - 502}
}
Background: Blue light was shown to reduce the activation of T cells and modulate cytokine release in vitro. Therefore, we investigated the efficacy of blue light in the treatment of eczema. Methods: A sample of 21 patients with mild to moderate eczema were locally treated with blue LED light (light-emitting diode, emission maximum: 453 nm). They received light treatment 3 times per week for 4 weeks. A contralateral control lesion remained untreated. Results: A total of 20 patients completed… 

Figures and Tables from this paper

Treatment of Atopic Dermatitis Using a Full-Body Blue Light Device (AD-Blue): Protocol of a Randomized Controlled Trial
TLDR
A multicenter, placebo-controlled, double-blinded, 3-armed, prospective, randomized controlled trial to investigate the efficacy and safety of full-body blue light devices compared with that of placebo irradiation for the treatment of atopic dermatitis.
Treatment of Atopic Dermatitis Using a Full-Body Blue Light Device (AD-Blue): Protocol of a Randomized Controlled Trial (Preprint)
TLDR
A multicenter, placebo-controlled, double-blinded, 3-armed, prospective, randomized controlled trial to investigate the efficacy and safety of full-body blue light devices compared with that of placebo irradiation for the treatment of atopic dermatitis.
Blue Light in Dermatology
TLDR
It was demonstrated that blue light induces an anti-inflammatory and antiproliferative effect; thus, it may be beneficial for hyperproliferative and chronic inflammatory skin diseases such as atopic dermatitis, eczema, and psoriasis and long-term safety should be monitored.
Photobiomodulation-blue and red LED: protection or cellular toxicity? In vitro study with human fibroblasts
TLDR
Blue and red light-emitting diode light showed less potential for cell protection due to the risk of associating more significant nitric oxide formation with increased reactive oxygen species formation, in addition to having a greater amount of extracellular DNA.
Advances in phototherapy for psoriasis and atopic dermatitis
TLDR
This review provides an update on the different forms of phototherapy used for the treatment of psoriasis and atopic dermatitis, including the immunosuppressive effect of UV light, the anti-inflammatory effect of vascular lasers and the LLLT induced photobiomodulation.
Blue light: Friend or foe ?
Neonatal Phototherapy: A Novel Therapy to Prevent Allergic Skin Disease for At Least 5 Years
  • M. Ku
  • Medicine
    Neonatology
  • 2018
TLDR
Blue light therapy in newborns may be a novel method to efficiently prevent allergic skin disease for at least 5 years, and the decreased use of topical agents could reach 64.29%.
Visible Blue Light Therapy: Molecular Mechanisms and Therapeutic Opportunities.
TLDR
To strengthen the use of blue light for therapeutic purposes, further in depth studies are clearly needed with regard to its underlying molecular and cellular mechanisms, and their translation into clinical applications.
Photodynamic and photobiological effects of light-emitting diode (LED) therapy in dermatological disease: an update
TLDR
The use of LED in the treatment of skin inflammatory conditions, aging, and disorders linked to hair growth has now entered common practice among dermatologists and additional controlled studies are still needed to corroborate the efficacy of such kind of treatment.
...
1
2
3
...

References

SHOWING 1-10 OF 18 REFERENCES
Prospective Randomized Long-Term Study on the Efficacy and Safety of UV-Free Blue Light for Treating Mild Psoriasis Vulgaris
TLDR
UV-free blue light home treatment is safe and improves psoriasis vulgaris plaques, and reveals a significant improvement of the target compared to the control plaques.
Prospective Randomized Study on the Efficacy of Blue Light in the Treatment of Psoriasis Vulgaris
TLDR
Blue light appears to be a promising treatment modality in PV that warrants further evaluation in larger studies, and plaque status as assessed by both the physicians and the patients improved continuously during the 4 weeks of treatment and steadily declined thereafter.
Clinical Efficacy of Blue Light Full Body Irradiation as Treatment Option for Severe Atopic Dermatitis
TLDR
Blue light-irradiation may represent a suitable treatment option for AD providing long term control of disease, and immunohistochemistry of skin biopsies obtained at baseline and after 5 and 15 days revealed that, unlike UV light, blue light-treatment did not induce Langerhans cell or T cell depletion from skin.
Blue light irradiation suppresses dendritic cells activation in vitro
TLDR
It is reported that irradiation neither induced apoptosis nor maturation of monocyte‐derived and myeloid DC, and subsequent DC maturation upon LPS/IFNγ stimulation was impaired in a dose‐dependent manner as assessed by maturation markers and cytokine release.
Blue-light irradiation regulates proliferation and differentiation in human skin cells.
TLDR
It is found that light at wavelengths of 632-940 nm has no effect, but irradiation with blue light at 412-426 nm exerts toxic effects at high fluences, which provides evidence for a molecular mechanism by which blue light may be effective in treating hyperproliferative skin conditions by reducing proliferation due to the induction of differentiation.
The eczema area and severity index (EASI): assessment of reliability in atopic dermatitis. EASI Evaluator Group.
TLDR
Overall intra-evaluator reliability of the EASI was in the fair-to-good range and there was consistency among the evaluators between consecutive days of evaluation, which support the use of theEASI in clinical trials of therapeutic agents for AD.
The eczema area and severity index (EASI): assessment of reliability in atopic dermatitis
TLDR
Overall intra‐evaluator reliability of the EASI was in the fair‐to‐good range and there was consistency among the evaluators between consecutive days of evaluation, which support the use of theEASI in clinical trials of therapeutic agents for AD.
Laser and other light therapies for the treatment of acne vulgaris: systematic review
TLDR
Laser and other light therapies have been reported to be convenient, safe and effective in treating acne and can lead to scarring of the skin and reduced self‐esteem.
Systematic review of treatments for atopic eczema.
TLDR
An up-to-date coverage 'map' of randomised controlled trials (RCTs) of treatments of atopic eczema is produced to assist in making treatment recommendations by summarising the available RCT evidence using qualitative and quantitative methods.
...
1
2
...