Prospecting for Camptothecines from Nothapodytes nimmoniana in the Western Ghats, South India: identification of high-yielding sources of camptothecin and new families of camptothecines.

@article{Ramesha2008ProspectingFC,
  title={Prospecting for Camptothecines from Nothapodytes nimmoniana in the Western Ghats, South India: identification of high-yielding sources of camptothecin and new families of camptothecines.},
  author={Bheemanahally Thimmappa Ramesha and Touseef Amna and Gudasalamani Ravikanth and Rajesh P Gunaga and Ramesh Vasudeva and Kotiganahalli Narayanagowda Ganeshaiah and Ramanan Uma Shaanker and Ravi Kant Khajuria and Satish Chandra Puri and Ghulam Nabi Qazi},
  journal={Journal of chromatographic science},
  year={2008},
  volume={46 4},
  pages={362-8}
}
Camptothecin (CPT), a monoterpene alkaloid, is an important anti-cancer compound obtained from several plant sources including Camptotheca acuminta (from China) and Nothapodytes nimmoniana (from India). Currently, by far the highest levels of CPT (approximately 0.3% w/w) are reported from Nothapodytes nimmoniana, a small tree distributed in the Western Ghats, India. In recent years because of the heavy demand, there has been a serious threat of extinction of the populations of the tree in the… CONTINUE READING