Prospect of rindopepimut in the treatment of glioblastoma.

  title={Prospect of rindopepimut in the treatment of glioblastoma.},
  author={Aladine A. Elsamadicy and Pakawat Chongsathidkiet and Rupen Desai and Karolina I Woroniecka and Samuel Harrison Farber and Peter Edward Fecci and John H. Sampson},
  journal={Expert opinion on biological therapy},
  volume={17 4},
INTRODUCTION Rindopepimut (CDX-110) is a peptide vaccine that targets epidermal growth factor receptor variant III (EGFRvIII), a tumor-specific epitope expressed in the most common and lethal primary malignant neoplasm of the brain - glioblastoma (GBM). Areas covered: The EGFRvIII mutation introduces an 801 base pair in-frame deletion of the extracellular domain of the transmembrane tyrosine kinase, resulting in constitutive kinase activity, amplification of cell growth, and inhibition of… CONTINUE READING
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