Prosaposin sorting is mediated by oligomerization.

  title={Prosaposin sorting is mediated by oligomerization.},
  author={Libin Yuan and Carlos R. Morales},
  journal={Experimental cell research},
  volume={317 17},
The compartmental nature of eukaryotic cells requires sophisticated mechanisms of protein sorting. Prosaposin, the precursor of four sphingolipid activator proteins, is transported from the trans-Golgi network (TGN) to lysosomes as a partially glycosylated (65 kDa) protein with high-mannose/hybrid oligosaccharides. Prosaposin is also found in the extracellular space where it is secreted as a fully glycosylated (70 kDa) protein composed of complex glycans. Although the trafficking of prosaposin… CONTINUE READING