Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin

@inproceedings{Zhou2015ProsaposinFS,
  title={Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin},
  author={Xiaolai Zhou and Lirong Sun and Francisco Meirelles Bastos de Oliveira and Xiaoyang Qi and William J. Brown and Marcus Bustamante Smolka and Ying Sun and Fenghua Hu},
  booktitle={The Journal of cell biology},
  year={2015}
}
Mutations in the progranulin (PGRN) gene have been linked to two distinct neurodegenerative diseases, frontotemporal lobar degeneration (FTLD) and neuronal ceroid lipofuscinosis (NCL). Accumulating evidence suggests a critical role of PGRN in lysosomes. However, how PGRN is trafficked to lysosomes is still not clear. Here we report a novel pathway for lysosomal delivery of PGRN. We found that prosaposin (PSAP) interacts with PGRN and facilitates its lysosomal targeting in both biosynthetic and… CONTINUE READING
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