Prosaposin Overexpression following Kainic Acid-Induced Neurotoxicity

Abstract

Because excessive glutamate release is believed to play a pivotal role in numerous neuropathological disorders, such as ischemia or seizure, we aimed to investigate whether intrinsic prosaposin (PS), a neuroprotective factor when supplied exogenously in vivo or in vitro, is up-regulated after the excitotoxicity induced by kainic acid (KA), a glutamate… (More)
DOI: 10.1371/journal.pone.0110534

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@inproceedings{Nabeka2014ProsaposinOF, title={Prosaposin Overexpression following Kainic Acid-Induced Neurotoxicity}, author={Hiroaki Nabeka and Keigo Uematsu and Hiroko Takechi and Tetsuya Shimokawa and Kimiko Yamamiya and Cheng Li and Takuya Doihara and Shouichiro Saito and Naoto Kobayashi and Seiji Matsuda}, booktitle={PloS one}, year={2014} }